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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

A Novel Synthesis Method of Apogossypolone and its Antitumor Activity

Author(s): Yonghua Zhan and Guangfeng Jia

Volume 6, Issue 2, 2009

Page: [129 - 132] Pages: 4

DOI: 10.2174/157018009787582589

Price: $65

Abstract

A derivative of gossypol, 6,7,6,7-Tetrahydroxy-5,5-diisopropyl-3,3-dimethyl-[2,2] binaphthalenyl- 1,4,1,4-tetraone (Apogossypolone, ApoG2), has been synthesized from gossypol acetic acid. Its structure was identified by IR, NMR, MS spectrum and cancer cells in vitro growth inhibition experiments were performed. The results indicate that apogossypolone exerts strong in vitro growth inhibition in human prostate cancer cells, representing a promising cancer therapeutic.

Keywords: Gossypol, Apogossypolone, Synthesis, In vitro growth inhibition, Proteins


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