Abstract
Calcineurin (CN) is a heterodimer of a catalytic subunit, calcineurin A (CNA), and a regulatory subunit (CNB). Here, we find that the mechanism by which CNB regulates CNA depends on the substrate involved. The regulation mechanism involving tau and its truncation segments is distinct from that involving RII peptide, and the efficiencies of CNA to dephosphorylate tau are constant regardless of whether CNB was present or not. The findings shed some light on the role of CNB in controlling phosphorylation of tau in vivo and the pathogenesis of tauopathies such as Alzheimers Disease.
Keywords: Calcineurin A subunit, calcineurin B subunit, tau, RII peptide, dephosphorylation, Alzheimer's Disease
Protein & Peptide Letters
Title: Different Regulation Modes of Calcineurin Regulatory Subunit on Its Catalytic Subunit with RII Peptide and Tau as Substrates
Volume: 16 Issue: 2
Author(s): Da-yu Yu, Nan Qiao, Ping Liu and Qun Wei
Affiliation:
Keywords: Calcineurin A subunit, calcineurin B subunit, tau, RII peptide, dephosphorylation, Alzheimer's Disease
Abstract: Calcineurin (CN) is a heterodimer of a catalytic subunit, calcineurin A (CNA), and a regulatory subunit (CNB). Here, we find that the mechanism by which CNB regulates CNA depends on the substrate involved. The regulation mechanism involving tau and its truncation segments is distinct from that involving RII peptide, and the efficiencies of CNA to dephosphorylate tau are constant regardless of whether CNB was present or not. The findings shed some light on the role of CNB in controlling phosphorylation of tau in vivo and the pathogenesis of tauopathies such as Alzheimers Disease.
Export Options
About this article
Cite this article as:
Yu Da-yu, Qiao Nan, Liu Ping and Wei Qun, Different Regulation Modes of Calcineurin Regulatory Subunit on Its Catalytic Subunit with RII Peptide and Tau as Substrates, Protein & Peptide Letters 2009; 16 (2) . https://dx.doi.org/10.2174/092986609787316243
DOI https://dx.doi.org/10.2174/092986609787316243 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anticancer Vitamin K3 Analogs: A Review
Anti-Cancer Agents in Medicinal Chemistry Adverse Reactions Induced by Minocycline: A Review of Literature
Current Drug Safety Endogenous Modulators of TRP Channels
Current Topics in Medicinal Chemistry Natural Polymeric Nanoparticles for Brain-Targeting: Implications on Drug and Gene Delivery
Current Pharmaceutical Design Pharmacology and Toxicology of Cannabis Derivatives and Endocannabinoid Agonists
Recent Patents on CNS Drug Discovery (Discontinued) Neuronutrient Amino-Acid Therapy Protects Against Reward Deficiency Syndrome: Dopaminergic Key to Homeostasis and Neuroplasticity
Current Pharmaceutical Design Effect of Ionic Strength on the Aggregation Propensity of Aβ<sub>1-42</sub> Peptide: An In-silico Study
Current Chemical Biology Design and Synthesis of New Selective P-gp Substrates and Inhibitors
Current Pharmaceutical Design Vitamin D as a Potential Therapeutic Option in Cancer Treatment: Is There a Role for Chemoprevention?
Anti-Cancer Agents in Medicinal Chemistry Neuropeptides, Neuropeptidases and Brain Asymmetry
Current Protein & Peptide Science Dermatologic Effects of Psychopharmacologic Agents in the Pediatric Population
Current Psychopharmacology Quality of Life and Social Support in Women with Urinary Incontinence
Current Women`s Health Reviews Endothelial Dysfunction and the Effects of TNF Inhibitors on the Endothelium in Psoriasis and Psoriatic Arthritis: A Systematic Review
Current Pharmaceutical Design The Association of Hot/Cold Status of Temperament with Depression and Hopelessness Scores in Females
Current Traditional Medicine Current Status and Future Prospects of Small–molecule Protein–protein Interaction (PPI) Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)
Current Topics in Medicinal Chemistry Meet Our Associate Editorial Board Member
Current Psychopharmacology Adolescent Admissions in Psychiatry: Reconsidering Clinical and Institutional Parameters on the Occasion of a Report of a Greek Experience
Adolescent Psychiatry Curcumin and Endothelial Function: Evidence and Mechanisms of Protective Effects
Current Pharmaceutical Design Alterations in the Peptidergic Regulation of Energy Balance in the Course of Aging
Current Protein & Peptide Science Randomized Placebo-Controlled Trials of Omega-3 Polyunsaturated Fatty Acids in Psychiatric Disorders: A Review of the Current Literature
Current Drug Discovery Technologies