Abstract
Here, we show for the first time that non-fibrillar and spherical aggregates produced from PrP-(23-98) in the presence of NADPH plus copper ions are toxic to cultured cells and induce apoptotic signals. It is also confirmed that endogenous cellular PrP isoform is not required for toxicity to occur.
Keywords: Prion protein, PrP-(23-98), aggregates, cytotoxicity, apoptosis, PrP-deficient cell line
Protein & Peptide Letters
Title: Proteinase K-Resistant Aggregates of Recombinant Prion Protein PrP-(23-98) Are Toxic to Cultured Cells
Volume: 16 Issue: 1
Author(s): Noriyuki Shiraishi, Yoko Inai and Yoshito Ihara
Affiliation:
Keywords: Prion protein, PrP-(23-98), aggregates, cytotoxicity, apoptosis, PrP-deficient cell line
Abstract: Here, we show for the first time that non-fibrillar and spherical aggregates produced from PrP-(23-98) in the presence of NADPH plus copper ions are toxic to cultured cells and induce apoptotic signals. It is also confirmed that endogenous cellular PrP isoform is not required for toxicity to occur.
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Cite this article as:
Shiraishi Noriyuki, Inai Yoko and Ihara Yoshito, Proteinase K-Resistant Aggregates of Recombinant Prion Protein PrP-(23-98) Are Toxic to Cultured Cells, Protein & Peptide Letters 2009; 16 (1) . https://dx.doi.org/10.2174/092986609787049475
DOI https://dx.doi.org/10.2174/092986609787049475 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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