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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Hydroxyl Radical Mediates Oxidative Modification of Caprine Alpha-2 Macroglobulin

Author(s): Shakil A. Khan and Fahim H. Khan

Volume 16, Issue 1, 2009

Page: [32 - 35] Pages: 4

DOI: 10.2174/092986609787049376

Price: $65

Abstract

ROS, including .OH, is now recognized as the hallmark of inflammation and damage to the anti-proteinase barrier has been implicated in a number of pathophysiological conditions. We have previously shown that O2 .- and H2O2/HOCl are physiologically relevant inactivators of α2M, a key anti-proteinase. Here, we show that .OH disrupted caprine α2M structure and antiproteolytic potential in vitro, suggesting that its function could be compromised via oxidative modification.

Keywords: Caprine, alpha-2-macroglobulin, hydroxyl radical


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