Abstract
ROS, including .OH, is now recognized as the hallmark of inflammation and damage to the anti-proteinase barrier has been implicated in a number of pathophysiological conditions. We have previously shown that O2 .- and H2O2/HOCl are physiologically relevant inactivators of α2M, a key anti-proteinase. Here, we show that .OH disrupted caprine α2M structure and antiproteolytic potential in vitro, suggesting that its function could be compromised via oxidative modification.
Keywords: Caprine, alpha-2-macroglobulin, hydroxyl radical
Protein & Peptide Letters
Title: Hydroxyl Radical Mediates Oxidative Modification of Caprine Alpha-2 Macroglobulin
Volume: 16 Issue: 1
Author(s): Shakil A. Khan and Fahim H. Khan
Affiliation:
Keywords: Caprine, alpha-2-macroglobulin, hydroxyl radical
Abstract: ROS, including .OH, is now recognized as the hallmark of inflammation and damage to the anti-proteinase barrier has been implicated in a number of pathophysiological conditions. We have previously shown that O2 .- and H2O2/HOCl are physiologically relevant inactivators of α2M, a key anti-proteinase. Here, we show that .OH disrupted caprine α2M structure and antiproteolytic potential in vitro, suggesting that its function could be compromised via oxidative modification.
Export Options
About this article
Cite this article as:
Khan A. Shakil and Khan H. Fahim, Hydroxyl Radical Mediates Oxidative Modification of Caprine Alpha-2 Macroglobulin, Protein & Peptide Letters 2009; 16 (1) . https://dx.doi.org/10.2174/092986609787049376
DOI https://dx.doi.org/10.2174/092986609787049376 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Microparticles in Health and Disease: Small Mediators, Large Role?
Current Vascular Pharmacology QSAR Studies of PTP1B Inhibitors: Recent Advances and Perspectives
Current Medicinal Chemistry Emerging Potential of Natural Products as an Alternative Strategy to Pharmacological Agents Used Against Metabolic Disorders
Current Drug Metabolism Current and Future Drugs for Appetite Regulation and Obesity Treatment
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Weight Loss in Older Persons: New Therapeutic Approaches
Current Pharmaceutical Design Evaluation of Intermediate Endpoints: Clinical Implications in the Management of Arterial Hypertension
Current Hypertension Reviews Toll-Like Receptor 4 and Heat-Shock Protein 70: Is it a New Target Pathway for Diabetic Vasculopathies?
Current Drug Targets Leptin Signaling in Blood Platelets as a Target for Therapeutic Intervention
Current Signal Transduction Therapy Therapeutic Effects of Progesterone in Animal Models of Neurological Disorders
CNS & Neurological Disorders - Drug Targets Review of Endocrine Manifestations of Antiphospholid Syndrome
Current Rheumatology Reviews Pharmacological and Non Pharmacological Strategies in the Management of Coronary Artery Disease and Chronic Kidney Disease
Current Cardiology Reviews Stroke Prevention: From Available Antiplatelet Drugs to Novel Molecular Targets
Current Drug Targets Pros and Cons of Aggressive Blood Pressure Lowering in Patients with Type 2 Diabetes
Current Vascular Pharmacology Adenoid Hypertrophy, Craniofacial Growth and Obstructive Sleep Apnea: A Crucial Triad in Children
Current Respiratory Medicine Reviews Prolyl-Specific Peptidases and Their Inhibitors in Biological Processes
Current Chemical Biology An Ethnomedicinal Survey of Antidiabetic Plants and Preliminary Evaluation of Antioxidant, Hypoglycemic Activity <i>Maesa indica</i> Leaves, a Folk Antidiabetic Plant of Manipur, India
Current Traditional Medicine Role of Advanced Glycation End Products (AGEs) and Oxidative Stress in Diabetic Retinopathy
Current Pharmaceutical Design Sympathetic Overactivity in Patients with Chronic Renal Failure - The Culprit of Increased Cardiovascular Mortality?
Current Hypertension Reviews Glucose and LDL Lowering: The Need for Intensive Therapy
Current Vascular Pharmacology The Leukocyte Common Antigen-Related Protein LAR: Candidate PTP for Inhibitory Targeting
Current Topics in Medicinal Chemistry