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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

The Stereoselective Total Synthesis of (1S,1R,5R,7R)-1-hydroxy-exo- Brevicomin by a Chiron Approach

Author(s): Jhillu S. Yadav, Kodepelly Sanjeeva Rao and Basi V. Subba Reddy

Volume 6, Issue 1, 2009

Page: [4 - 7] Pages: 4

DOI: 10.2174/157017809787003197

Price: $65

Abstract

(1S,1R,5R,7R)-1-Hydroxy-exo-brevicomin has been synthesized in a highly efficient manner using Dglucono- δ-lactone as a chiral precursor. The synthesis involves the Grignard cross coupling, Wacker oxidation and intramolecular acetalization as the key steps.

Keywords: D-glucono-δ-lactone, grignard cross coupling, wacker oxidation, acetalization, exo-brevicomin


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