Abstract
Many important biological processes including fertilization, tissue formation, cell adhesion, antigen/antibody interactions, cancer metastasis or pathogen infection involve polyvalent interactions between oligomeric proteins and carbohydrate-based ligands. The synthesis of multitopic, molecularly-defined structures that display both clustered sugars and immobilization or bioactive agents represents an attractive approach for the discovery of new diagnostics and therapeutics. This mini-review updates the current developments in this field by focusing on the recent interests on cyclopeptide-based glycoclusters.
Keywords: Cyclopeptide, glycocluster, multivalency, carbohydrate, solid-phase synthesis, oxime ligation
Mini-Reviews in Organic Chemistry
Title: Recent Advances on Cyclopeptide-Based Glycoclusters
Volume: 5 Issue: 4
Author(s): Olivier Renaudet
Affiliation:
Keywords: Cyclopeptide, glycocluster, multivalency, carbohydrate, solid-phase synthesis, oxime ligation
Abstract: Many important biological processes including fertilization, tissue formation, cell adhesion, antigen/antibody interactions, cancer metastasis or pathogen infection involve polyvalent interactions between oligomeric proteins and carbohydrate-based ligands. The synthesis of multitopic, molecularly-defined structures that display both clustered sugars and immobilization or bioactive agents represents an attractive approach for the discovery of new diagnostics and therapeutics. This mini-review updates the current developments in this field by focusing on the recent interests on cyclopeptide-based glycoclusters.
Export Options
About this article
Cite this article as:
Renaudet Olivier, Recent Advances on Cyclopeptide-Based Glycoclusters, Mini-Reviews in Organic Chemistry 2008; 5 (4) . https://dx.doi.org/10.2174/157019308786242142
DOI https://dx.doi.org/10.2174/157019308786242142 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Glycyrrhetinic Acid and Its Derivatives: Anti-Cancer and Cancer Chemopreventive Properties, Mechanisms of Action and Structure- Cytotoxic Activity Relationship
Current Medicinal Chemistry The Antidepressant-like Effects of Estrogen-mediated Ghrelin
Current Neuropharmacology Cytokines and their Antagonists as Therapeutic Agents
Current Medicinal Chemistry Potential Therapeutic Applications of MDA-9/Syntenin-NF-κB-RKIP Loop in Human Liver Carcinoma
Current Molecular Medicine Ethanol Extract of Achillea fragrantissima Enhances Angiogenesis through Stimulation of VEGF Production
Endocrine, Metabolic & Immune Disorders - Drug Targets Targeting Cancer Cells with Photoactive Silica Nanoparticles
Current Pharmaceutical Design Circular RNAs and Glioma: Small Molecule with Big Actions
Current Molecular Medicine Recent Progress in the Identification and Clinical Evaluation of Inhibitors of the Mitotic Kinesin KSP
Current Topics in Medicinal Chemistry Regulation of Tumor Angiogenesis by the Immune System
Current Angiogenesis (Discontinued) BUB1B Promotes Proliferation of Prostate Cancer via Transcriptional Regulation of MELK
Anti-Cancer Agents in Medicinal Chemistry Molecular Targets from VHL Studies into the Oxygen-Sensing Pathway
Current Cancer Drug Targets Recent Advancement in the Treatment of Cardiovascular Diseases: Conventional Therapy to Nanotechnology
Current Pharmaceutical Design Ubiquitylation and Cancer Development
Current Cancer Drug Targets Implication of Prophetic Variables and their Impulsive Interplay in CA Prostate Patients Experiencing Osteo-Metastasis
Anti-Cancer Agents in Medicinal Chemistry Treatment of Leishmaniasis: A Review and Assessment of Recent Research
Current Pharmaceutical Design Health Beneficial Potential of Pectolinarigenin on Human Diseases: An Updated Review of Medicinal Importance and Pharmacological Activity
The Natural Products Journal Recent Advance in the Research of Flavonoids as Anticancer Agents
Mini-Reviews in Medicinal Chemistry Identification and Usage of Fluorescent Probes as Nanoparticle Contrast Agents in Detecting Cancer
Current Pharmaceutical Design Patent Annotations
Recent Patents on Anti-Cancer Drug Discovery Novel Thiourea Derivatives Bearing Sulfonamide Moiety as Anticancer Agents Through COX-2 Inhibition
Anti-Cancer Agents in Medicinal Chemistry