Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions

Title: Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions

Volume: 5 Issue: 7

Author(s): Mei Xiao, Hongsong Yang, Suzane M. Klein, Christian M. Muenyi, William L. Stone and Yu L. Jiang

Affiliation:

Keywords: Anticancer drug, NCX 4040, design, synthesis, mild conditions, LNCaP cancer cell lines, prostate cancer

Abstract: A simple method is reported to synthesize an anticancer drug, NCX 4040, conveniently in mild conditions using silicon chemistry. A starting material, 4-hydroxybenzyl alcohol, was silylated selectively first to give tbutyldimethylsilyl 4-hydroxybenzyl ether, which was then converted to NCX 4040 by esterification, desilylation, hydrochlorination and nitration.

Cite this article as:

Xiao Mei, Yang Hongsong, Klein M. Suzane, Muenyi M. Christian, Stone L. William and Jiang L. Yu, Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions, Letters in Organic Chemistry 2008; 5 (7) . https://dx.doi.org/10.2174/157017808785982257