Abstract
A number of urea derivatives were synthesized and screened for their urease and α-chymotrypsin inhibition effects, whereby one of the compounds, N-4-nitrophenyl-N’-4’-nitrophenylurea (3), showed strong urease inhibition (IC50 = 1.25μM). We found that the same compound is also an efficient α-chymotrypsin inhibitor having an IC50 value of 3.15μM.
Keywords: Urease, α-chymotrypsin, Urea derivatives
Letters in Drug Design & Discovery
Title: Urease and α-Chymotrypsin Inhibitory Effects of Selected Urea Derivatives
Volume: 5 Issue: 6
Author(s): Shahnaz Perveen, Khalid Mohammed Khan, Muhammad Arif Lodhi, Muhammad Iqbal Choudhary, Atta-ur-Rahman and Wolfgang Voelter
Affiliation:
Keywords: Urease, α-chymotrypsin, Urea derivatives
Abstract: A number of urea derivatives were synthesized and screened for their urease and α-chymotrypsin inhibition effects, whereby one of the compounds, N-4-nitrophenyl-N’-4’-nitrophenylurea (3), showed strong urease inhibition (IC50 = 1.25μM). We found that the same compound is also an efficient α-chymotrypsin inhibitor having an IC50 value of 3.15μM.
Export Options
About this article
Cite this article as:
Perveen Shahnaz, Khan Mohammed Khalid, Lodhi Arif Muhammad, Choudhary Iqbal Muhammad, Atta-ur-Rahman and Voelter Wolfgang, Urease and α-Chymotrypsin Inhibitory Effects of Selected Urea Derivatives, Letters in Drug Design & Discovery 2008; 5 (6) . https://dx.doi.org/10.2174/157018008785777315
DOI https://dx.doi.org/10.2174/157018008785777315 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Conjugates of Natural Compounds with Nitroxyl Radicals as a Basis for Creation of Pharmacological Agents of New Generation
Current Medicinal Chemistry Mitochondrial Generation of Reactive Oxygen Species and its Role in Aerobic Life
Current Medicinal Chemistry MicroRNAs-based Therapy: A Novel and Promising Strategy for Cancer Treatment
MicroRNA Cancer Gene Therapy Utilizing Interleukin-13 Receptor α2 Chain
Current Gene Therapy Selective VEGFR Inhibitors for Anticancer Therapeutics in Clinical Use and Clinical Trials
Current Pharmaceutical Design Biocompatible Delivery System for Metformin: Characterization, Radiolabeling and In Vitro Studies
Anti-Cancer Agents in Medicinal Chemistry A2A Adenosine Receptor Antagonists as Therapeutic Candidates: Are They Still an Interesting Challenge?
Mini-Reviews in Medicinal Chemistry Role of PARP Inhibitors in Cancer Biology and Therapy
Current Medicinal Chemistry Chromosomal Abnormalities, Cancer and Mouse Models The Critical Role of Translocation-Associated Genes in Human Cancer
Current Genomics The Chemistry of Bioactive Diterpenes
Current Organic Chemistry Targeting JAK/STAT Signaling Pathway in Inflammatory Diseases
Current Signal Transduction Therapy Carbon Nanotubes: Classification, Method of Preparation and Pharmaceutical Application
Current Drug Delivery ABC Transporters in the Development of Multidrug Resistance in Cancer Therapy
Current Pharmaceutical Design Development of <sup>186/188</sup>Re-Chitosan as an Effective Therapeutic Agent for Rheumatoid Arthritis
Current Radiopharmaceuticals Leptin, Ciliary Neurotrophic Factor, Leukemia Inhibitory Factor and Interleukin- 6: Class-I Cytokines Involved in the Neuroendocrine Regulation of the Reproductive Function
Current Protein & Peptide Science Perspectives in Biomolecular Therapeutic Intervention in Cancer: From the Early to the New Strategies With Type I Interferons
Current Medicinal Chemistry Nanofibers: New Insights for Drug Delivery and Tissue Engineering
Current Topics in Medicinal Chemistry Endocannabinoids in Liver Disease and Hepatic Encephalopathy
Current Pharmaceutical Design Serotonin and Cancer: What Is the Link?
Current Molecular Medicine Poly(ADP-ribose)polymerase Inhibition - Where Now?
Current Medicinal Chemistry