Abstract
The development of a new generation of vaccines that can be produced rapidly at low costs and massadministered noninvasively by non-medical personnel is crucial for boosting vaccine coverage in response to an escalation in demand. The demonstration that topical application of bioengineered nonreplicating Escherichia coli particles overproducing pathogen-derived antigens can mobilize the immune repertoire toward beneficial immune protection against relevant pathogens holds promise for enabling mass-immunization without pain, fear and perceivable tissue damage. Moreover, this noninvasive regimen using E. coli epitopes as a natural adjuvant is in compliance with evolutionary medicine.
Keywords: Skin, stratum corneum, Escherichia coli, γ-irradiation, noninvasive vaccine, epicutaneous immunization
Infectious Disorders - Drug Targets
Title: Topical Application of Escherichia coli Particles Over-Producing Pathogen-Derived Antigens as a Simple Vaccination Modality in Compliance with Evolutionary Medicine
Volume: 8 Issue: 3
Author(s): Jianfeng Zhang and De-chu C. Tang
Affiliation:
Keywords: Skin, stratum corneum, Escherichia coli, γ-irradiation, noninvasive vaccine, epicutaneous immunization
Abstract: The development of a new generation of vaccines that can be produced rapidly at low costs and massadministered noninvasively by non-medical personnel is crucial for boosting vaccine coverage in response to an escalation in demand. The demonstration that topical application of bioengineered nonreplicating Escherichia coli particles overproducing pathogen-derived antigens can mobilize the immune repertoire toward beneficial immune protection against relevant pathogens holds promise for enabling mass-immunization without pain, fear and perceivable tissue damage. Moreover, this noninvasive regimen using E. coli epitopes as a natural adjuvant is in compliance with evolutionary medicine.
Export Options
About this article
Cite this article as:
Zhang Jianfeng and Tang C. De-chu, Topical Application of Escherichia coli Particles Over-Producing Pathogen-Derived Antigens as a Simple Vaccination Modality in Compliance with Evolutionary Medicine, Infectious Disorders - Drug Targets 2008; 8 (3) . https://dx.doi.org/10.2174/1871526510808030189
DOI https://dx.doi.org/10.2174/1871526510808030189 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Meet Our Editorial Board Member
Current Pharmaceutical Biotechnology The Vitamin D/CYP24A1 Story in Cancer
Anti-Cancer Agents in Medicinal Chemistry Role of Proinflammatory Cytokines in Dopaminergic System Disturbances, Implications for Anhedonic Features of MDD
Current Pharmaceutical Design Medications Affecting Functional Status in Older Persons
Current Pharmaceutical Design Revisiting the Antiviral Efficacy of Terpenoids: Plausible Adjunct Therapeutics for Novel SARS-CoV-2?
Endocrine, Metabolic & Immune Disorders - Drug Targets The Regulation Role of Ferroptosis Mechanism of Anti-Cancer Drugs and Noncoding RNAs
Current Medicinal Chemistry Novel Functions of MicroRNA-17-92 Cluster in the Endocrine System
Current Drug Targets Implications of Somatic Mutations in the AML1/RUNX1 Gene in Myelodysplastic Syndrome (MDS): Future Molecular Therapeutic Directions for MDS
Current Cancer Drug Targets Ischemic and Oxidative Damage to the Hypothalamus May Be Responsible for Heat Stroke
Current Neuropharmacology Stem Cell Transplantation for Hematological Malignancies: Prospects for Personalized Medicine and Co-therapy with Mesenchymal Stem Cells
Current Pharmacogenomics and Personalized Medicine Cyclooxygenase and Atherosclerosis: A Smoking Area
Current Pharmaceutical Design Arginine Deprivation as a Targeted Therapy for Cancer
Current Pharmaceutical Design Effect of Boswellia serrata on Rat Trachea Contractility In Vitro
The Natural Products Journal Chemistry and Biology of Anti-Inflammatory Marine Natural Products. Phospholipase A2 Inhibitors
Current Organic Chemistry Concepts for Nano-delivery of Therapeutic Immunomodulatory Agents
Current Bionanotechnology (Discontinued) Determination of Dysregulated miRNA Expression Levels by qRT-PCR after the Application of Usnic Acid to Breast Cancer
Anti-Cancer Agents in Medicinal Chemistry COVID-19: An Update on Pathogenesis and Treatment
Current Pharmaceutical Design Prevalence and Predictors of Self-Medication Practices in India: A Systematic Literature Review and Meta-Analysis
Current Clinical Pharmacology Predictive Biomarkers and Novel Targets in the Treatment of Metastatic Renal Cell Carcinoma
Current Medicinal Chemistry Prediction of Citrullination Sites on the Basis of mRMR Method and SNN
Combinatorial Chemistry & High Throughput Screening