Bi(OTf)3 as Mild, Efficient and Cost-Effective Catalyst for the Alkylation of N-Heterocycles with Epoxides

Title: Bi(OTf)3 as Mild, Efficient and Cost-Effective Catalyst for the Alkylation of N-Heterocycles with Epoxides

Volume: 5 Issue: 6

Author(s): Jhillu S. Yadav, Basi V. Subbareddy, Avvaru D. Krishna, Ailuri R. Reddy and Akkirala V. Narsaiah

Affiliation:

Keywords: Epoxides, bismuth compounds, N-heterocycles, tryptophol derivatives

Abstract: Epoxides undergo smooth ring opening with N-heterocyclic compounds such as indoles and pyrroles in the presence of a catalytic amount of bismuth triflate under mild conditions to produce C-alkylated indole and pyrrole derivatives in high yields with a high regioselectivity. Imidazole and benzotriazole affords N-alkylated products under identical conditions.

Cite this article as:

Yadav S. Jhillu, Subbareddy V. Basi, Krishna D. Avvaru, Reddy R. Ailuri and Narsaiah V. Akkirala, Bi(OTf)3 as Mild, Efficient and Cost-Effective Catalyst for the Alkylation of N-Heterocycles with Epoxides, Letters in Organic Chemistry 2008; 5 (6) . https://dx.doi.org/10.2174/157017808785740453