Abstract
A variety of TBDMS ethers were directly transprotected into their acetates/benzoates with acetyl chloride/ benzoyl chloride in a one-pot procedure using CuBr2 (30 mol%). Chemo-selective transprotection of aliphatic TBDMS ethers in the presence of aromatic TBDMS ethers was achieved using 10 mol% of the catalyst. Various sensitive functional groups such as ketals, ketones, alkenes, allyl and benzyl ethers were found to be compatible under the reaction conditions.
Keywords: TBDMS ethers, copper(II) bromide, transprotection, acetates, benzoates, chemoselectivity
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
13