Abstract
Azathioprine is an immunosuppressive and steroid-sparing purine analogue, used in the treatment of several autoimmune diseases. In multiple sclerosis, available evidence suggests that oral azathioprine reduces relapse rates, provides a slight benefit on disability, and reduces new inflammatory lesions. Here, we focus on molecular mechanisms of Azathioprine and on its usefulness in multiple sclerosis.
Keywords: Azathioprine, multiple sclerosis, immunosuppression, thiopurine methyltransferase, tolerability, relapses, disability, immunomodulators
Mini-Reviews in Medicinal Chemistry
Title: Azathioprine in Multiple Sclerosis
Volume: 8 Issue: 9
Author(s): Paolo Invernizz, Maria Donata Benedetti, Sarah Poli and Salvatore Monaco
Affiliation:
Keywords: Azathioprine, multiple sclerosis, immunosuppression, thiopurine methyltransferase, tolerability, relapses, disability, immunomodulators
Abstract: Azathioprine is an immunosuppressive and steroid-sparing purine analogue, used in the treatment of several autoimmune diseases. In multiple sclerosis, available evidence suggests that oral azathioprine reduces relapse rates, provides a slight benefit on disability, and reduces new inflammatory lesions. Here, we focus on molecular mechanisms of Azathioprine and on its usefulness in multiple sclerosis.
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Cite this article as:
Invernizz Paolo, Benedetti Donata Maria, Poli Sarah and Monaco Salvatore, Azathioprine in Multiple Sclerosis, Mini-Reviews in Medicinal Chemistry 2008; 8 (9) . https://dx.doi.org/10.2174/138955708785132756
DOI https://dx.doi.org/10.2174/138955708785132756 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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