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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Azathioprine in Multiple Sclerosis

Author(s): Paolo Invernizz, Maria Donata Benedetti, Sarah Poli and Salvatore Monaco

Volume 8, Issue 9, 2008

Page: [919 - 926] Pages: 8

DOI: 10.2174/138955708785132756

Price: $65

Abstract

Azathioprine is an immunosuppressive and steroid-sparing purine analogue, used in the treatment of several autoimmune diseases. In multiple sclerosis, available evidence suggests that oral azathioprine reduces relapse rates, provides a slight benefit on disability, and reduces new inflammatory lesions. Here, we focus on molecular mechanisms of Azathioprine and on its usefulness in multiple sclerosis.

Keywords: Azathioprine, multiple sclerosis, immunosuppression, thiopurine methyltransferase, tolerability, relapses, disability, immunomodulators


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