Abstract
Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.
Keywords: Atherosclerosis, apoptosis, pathogenesis
Mini-Reviews in Medicinal Chemistry
Title: Apoptosis in Atherosclerosis: A Mini-Review
Volume: 8 Issue: 9
Author(s): Maria Karaflou, Irene Lambrinoudaki and George Christodoulakos
Affiliation:
Keywords: Atherosclerosis, apoptosis, pathogenesis
Abstract: Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.
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Cite this article as:
Karaflou Maria, Lambrinoudaki Irene and Christodoulakos George, Apoptosis in Atherosclerosis: A Mini-Review, Mini-Reviews in Medicinal Chemistry 2008; 8 (9) . https://dx.doi.org/10.2174/138955708785132765
DOI https://dx.doi.org/10.2174/138955708785132765 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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