Discovery of AX8312, an N-alkyl-Gly-boro-Pro Derivative that Accelerates Recovery from Neutropenia in the Mouse

Title: Discovery of AX8312, an N-alkyl-Gly-boro-Pro Derivative that Accelerates Recovery from Neutropenia in the Mouse

Volume: 5 Issue: 5

Author(s): Emme C.K. Lin, Kevin R. Shreder, Melissa C. Zhang, Yi Hu, Lisa Morera, Min Wu, Melissa S. Wong, Lifu Ma, Doris Chun, Sergio Corral and John W. Kozarich

Affiliation:

Keywords: N-alkyl-Gly-boro-Pro, G-CSF, Neutropenia, Cytokine, AX8312

Abstract: A screen of N-alkyl-Gly-boro-Pro DPP inhibitors using an acute murine model revealed that N-adamantyl and N-cycloalkyl groups greater in size than cyclobutyl significantly induced G-CSF. Treatment of neutropenic mice with the most efficacious compound, AX8312 (N-(1-adamantyl)-Gly-boro-Pro), resulted in a faster and greater neutrophil recovery versus vehicle-treated mice.

Cite this article as:

Lin C.K. Emme, Shreder R. Kevin, Zhang C. Melissa, Hu Yi, Morera Lisa, Wu Min, Wong S. Melissa, Ma Lifu, Chun Doris, Corral Sergio and Kozarich W. John, Discovery of AX8312, an N-alkyl-Gly-boro-Pro Derivative that Accelerates Recovery from Neutropenia in the Mouse, Letters in Drug Design & Discovery 2008; 5 (5) . https://dx.doi.org/10.2174/157018008784912081