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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Function Prediction for DNA-/RNA-Binding Proteins, GPCRs, and Drug ADME-Associated Proteins by SVM

Author(s): Congzhong Cai, Hanguang Xiao, Qianfei Yuan, Xinghua Liu and Yufeng Wen

Volume 15, Issue 5, 2008

Page: [463 - 468] Pages: 6

DOI: 10.2174/092986608784567528

Price: $65

Abstract

This paper explores the use of support vector machine (SVM) for protein function prediction. Studies are conducted on several groups of proteins with different functions including DNA-binding proteins, RNA-binding proteins, Gprotein coupled receptors, drug absorption proteins, drug metabolizing enzymes, drug distribution and excretion proteins. The computed accuracy for the prediction of these proteins is found to be in the range of 82.32% to 99.7%, which illustrates the potential of SVM in facilitating protein function prediction.

Keywords: Protein function prediction, DNA-binding proteins, RNA-binding proteins, G-protein coupled receptors (GPCRs), drug absorption proteins, drug metabolizing enzymes, drug distribution and excretion proteins, support vector machine (SVM)


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