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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis of 5-Arylidene Barbiturates: A Novel Class of DPPH Radical Scavengers

Author(s): Khalid M. Khan, Muhammad Ali, Asma Ajaz, Shahnaz Perveen, M. Iqbal Choudhary and Atta-ur-Rahman

Volume 5, Issue 4, 2008

Page: [286 - 291] Pages: 6

DOI: 10.2174/157018008784619889

Price: $65

Abstract

Arylidene barbiturates 2-19 have been synthesized and their antioxidant and cytotoxic potentials have been evaluated. These compounds showed a moderate to excellent antioxidant activity in relevant antioxidant assay with no toxicity. A structure-activity relationship has been discussed. All the compounds were fully characterized by spectroscopic techniques.

Keywords: Barbiturates, DPPH, Antioxidant, Cytotoxic, Diseases


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