Abstract
Arylidene barbiturates 2-19 have been synthesized and their antioxidant and cytotoxic potentials have been evaluated. These compounds showed a moderate to excellent antioxidant activity in relevant antioxidant assay with no toxicity. A structure-activity relationship has been discussed. All the compounds were fully characterized by spectroscopic techniques.
Keywords: Barbiturates, DPPH, Antioxidant, Cytotoxic, Diseases
Letters in Drug Design & Discovery
Title: Synthesis of 5-Arylidene Barbiturates: A Novel Class of DPPH Radical Scavengers
Volume: 5 Issue: 4
Author(s): Khalid M. Khan, Muhammad Ali, Asma Ajaz, Shahnaz Perveen, M. Iqbal Choudhary and Atta-ur-Rahman
Affiliation:
Keywords: Barbiturates, DPPH, Antioxidant, Cytotoxic, Diseases
Abstract: Arylidene barbiturates 2-19 have been synthesized and their antioxidant and cytotoxic potentials have been evaluated. These compounds showed a moderate to excellent antioxidant activity in relevant antioxidant assay with no toxicity. A structure-activity relationship has been discussed. All the compounds were fully characterized by spectroscopic techniques.
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Cite this article as:
Khan M. Khalid, Ali Muhammad, Ajaz Asma, Perveen Shahnaz, Choudhary Iqbal M. and Atta-ur-Rahman , Synthesis of 5-Arylidene Barbiturates: A Novel Class of DPPH Radical Scavengers, Letters in Drug Design & Discovery 2008; 5 (4) . https://dx.doi.org/10.2174/157018008784619889
DOI https://dx.doi.org/10.2174/157018008784619889 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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