Design and Synthesis of Carbohydrate Derivatives for Antagonistic Activity at Muscarinic Receptor

Title: Design and Synthesis of Carbohydrate Derivatives for Antagonistic Activity at Muscarinic Receptor

Volume: 5 Issue: 4

Author(s): David R. da Rocha, Vitor F. Ferreira, Lucia Garcez-do-Carmo and Wilson C. Santos

Affiliation:

Keywords: Carbohydrates, Cholinergic neurotransmission, Muscarinic receptor, Atropine

Abstract: Effects of carbohydrate derivatives, synthesized exploring D-Glucose as starting material were studied in rat jejunum and tested in the muscarinic neurotransmission. The compounds shifted rightward and reduced maximum effect of curves for ACh. In KCl curves, they produced relaxing effects. Based on these experiments we suggest that these compounds act as non-competitive antagonists.

Cite this article as:

da Rocha R. David, Ferreira F. Vitor, Garcez-do-Carmo Lucia and Santos C. Wilson, Design and Synthesis of Carbohydrate Derivatives for Antagonistic Activity at Muscarinic Receptor, Letters in Drug Design & Discovery 2008; 5 (4) . https://dx.doi.org/10.2174/157018008784619870