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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Sialoglycotherapeutics in Protozoal Diseases

Author(s): Angana Ghoshal, Sumi Mukhopadhyay nee Bandyopadhyay and Chitra Mandal

Volume 8, Issue 4, 2008

Page: [358 - 369] Pages: 12

DOI: 10.2174/138955708783955980

Price: $65

Abstract

The manipulation of glycosylation, mainly sialylation, holds enormous potential for understanding the biological functions of glycoproteins and glycolipids to treat many diseases. The existing knowledge in the field of glycobiology is exploited by glycotherapeutics for combating protozoan diseases. This review focuses on the development of novel glycobiological therapeutic strategies in the field of protozoan infections.

Keywords: Anti-O-acetylated sialoglycoprotein specific antibodies, anti-α-gal antibodies, carbohydrate engineering, drug delivery, engineering inhibitors of glycoproteins, glycotherapeutics, glycovaccine, immunotoxin, metabolite oligosaccharide engineering, oligosaccharide engineering


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