Abstract
The platelet is an anucleate cell, complicating efforts to study platelet function by traditional genetic means. Discovery-based strategies have lead to the identification of pharmacological agents capable of targeting specific proteins critical for platelet activation. This review will address the evolution of discovery-based strategies to identify probes that are at once useful reagents for studying platelet activation and effective therapeutics.
Keywords: Platelets, chemical genetics, bioinformatics
Mini-Reviews in Medicinal Chemistry
Title: Discovery-Based Strategies for Studying Platelet Function
Volume: 8 Issue: 4
Author(s): R. Flaumenhaft and J. R. Dilks
Affiliation:
Keywords: Platelets, chemical genetics, bioinformatics
Abstract: The platelet is an anucleate cell, complicating efforts to study platelet function by traditional genetic means. Discovery-based strategies have lead to the identification of pharmacological agents capable of targeting specific proteins critical for platelet activation. This review will address the evolution of discovery-based strategies to identify probes that are at once useful reagents for studying platelet activation and effective therapeutics.
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Cite this article as:
Flaumenhaft R. and Dilks R. J., Discovery-Based Strategies for Studying Platelet Function, Mini-Reviews in Medicinal Chemistry 2008; 8 (4) . https://dx.doi.org/10.2174/138955708783955971
DOI https://dx.doi.org/10.2174/138955708783955971 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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