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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Discovery-Based Strategies for Studying Platelet Function

Author(s): R. Flaumenhaft and J. R. Dilks

Volume 8, Issue 4, 2008

Page: [350 - 357] Pages: 8

DOI: 10.2174/138955708783955971

Price: $65

Abstract

The platelet is an anucleate cell, complicating efforts to study platelet function by traditional genetic means. Discovery-based strategies have lead to the identification of pharmacological agents capable of targeting specific proteins critical for platelet activation. This review will address the evolution of discovery-based strategies to identify probes that are at once useful reagents for studying platelet activation and effective therapeutics.

Keywords: Platelets, chemical genetics, bioinformatics


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