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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Carbonyl-Scavenging Drugs & Protection Against Carbonyl Stress-Associated Cell Injury

Author(s): P. C. Burcham, L. M. Kaminskas, D. Tan and S. M. Pyke

Volume 8, Issue 4, 2008

Page: [319 - 330] Pages: 12

DOI: 10.2174/138955708783955953

Price: $65

Abstract

This mini-review highlights the chemical and cytoprotective properties of various hydralazine analogues that block the induction of cell death by acrolein, a highly toxic contributor to “carbonyl stress” during a diverse range of human diseases. Recent work on the action of hydralazine against various carbonyl-mediated pathologies is also reviewed.

Keywords: Carbonyl stress, acrolein, protein adducts, hydralazine


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