Synthesis and Biological Activity of New Tricyclic Purine Derivatives Obtained by Intramolecular N-7 Alkylation

Title: Synthesis and Biological Activity of New Tricyclic Purine Derivatives Obtained by Intramolecular N-7 Alkylation

Volume: 5 Issue: 2

Author(s): Arturene Maria Lino Carmo, Fernanda Gambogi Braga, Marcio Luiz De Paula, Ana Paula Ferreira, Henrique Couto Teixeira, Adilson David da Silva and Elaine Soares Coimbra

Affiliation:

Keywords: Purine analogues, Antileishmania, Anticancer, NO production

Abstract: Intramolecular N-7 alkylation of 6-substituted purines gave rise to a new series of tricyclic purine derivatives. The new compounds were evaluated for their cytotoxicity, their antileishmania activity together with their capacity to modulate NO production in macrophages. As a result compound 1 exhibited a modest activity against KB cells. On the other hand 4a was active against Leishmania and it diminished NO production of BCG-induced J774A.1 cells.

Cite this article as:

Lino Carmo Maria Arturene, Braga Gambogi Fernanda, De Paula Luiz Marcio, Ferreira Paula Ana, Teixeira Couto Henrique, da Silva David Adilson and Coimbra Soares Elaine, Synthesis and Biological Activity of New Tricyclic Purine Derivatives Obtained by Intramolecular N-7 Alkylation, Letters in Drug Design & Discovery 2008; 5 (2) . https://dx.doi.org/10.2174/157018008783928535