Abstract
Although there have been extensive research efforts to create functional tissues and organs, most successes in tissue engineering have been limited to avascular or thin tissues. The major hurdle in development of more complex tissues lies in the formation of vascular networks capable of delivering oxygen and nutrients throughout the engineered constructs. Sufficient neovascularization in scaffold materials can be achieved through coordinated application of angiogenic factors with proper cell types in biomaterials. This review present the current research developments in the design of biomaterials and their biochemical and biochemical modifications to produce vascularized tissue constructs.
Keywords: Tissue engineering, vascularization, angiogenesis, scaffold, biomaterials
Current Topics in Medicinal Chemistry
Title: Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials
Volume: 8 Issue: 4
Author(s): Jennifer L. West and James J. Moon
Affiliation:
Keywords: Tissue engineering, vascularization, angiogenesis, scaffold, biomaterials
Abstract: Although there have been extensive research efforts to create functional tissues and organs, most successes in tissue engineering have been limited to avascular or thin tissues. The major hurdle in development of more complex tissues lies in the formation of vascular networks capable of delivering oxygen and nutrients throughout the engineered constructs. Sufficient neovascularization in scaffold materials can be achieved through coordinated application of angiogenic factors with proper cell types in biomaterials. This review present the current research developments in the design of biomaterials and their biochemical and biochemical modifications to produce vascularized tissue constructs.
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Cite this article as:
West L. Jennifer and Moon J. James, Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials, Current Topics in Medicinal Chemistry 2008; 8 (4) . https://dx.doi.org/10.2174/156802608783790983
DOI https://dx.doi.org/10.2174/156802608783790983 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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