Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Structure Activity Relationship of Discodermolide Analogues

Author(s): Simon J. Shaw

Volume 8, Issue 3, 2008

Page: [276 - 284] Pages: 9

DOI: 10.2174/138955708783744137

Price: $65

Abstract

The marine polyketide discodermolide is a member of a class of natural products that stabilize microtubules. Many analogues have been synthesized suggesting that few changes can be made to the internal carbon backbone. Both ends of the molecule, however, can be modified. The majority of analogues have been generated via modification of the lactone region. This suggests that significant simplifications can be made in this region provided that the lactone moiety is maintained.

Keywords: lactone ring, Dictyostatin, pharmacokinetics, MDR cell line, SAR


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy