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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Strategies for In Vivo siRNA Delivery in Cancer

Author(s): Anil K. Sood, Angela Sanguino and Gabriel Lopez-Berestein

Volume 8, Issue 3, 2008

Page: [248 - 255] Pages: 8

DOI: 10.2174/138955708783744074

Price: $65

Abstract

A better understanding of the mechanisms involved in small interference RNA (siRNA) gene silencing opens new horizons for the development of the targeted therapy of malignant and benign diseases. As a research tool, siRNA has proven to be highly effective in silencing specific genes and modulating intracellular signaling pathways. However, systemic delivery of siRNA has been more problematic due to degradation and poor cellular uptake. In order to overcome these limitations, a variety of strategies are being developed including new delivery vehicles and chemical modifications. Here, we review potential approaches for the systemic delivery of siRNA for cancer treatment.

Keywords: SiRNA sequences, polyethylene glycol, folate receptor, Antibodies, Positively charged polymers


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