Abstract
A better understanding of the mechanisms involved in small interference RNA (siRNA) gene silencing opens new horizons for the development of the targeted therapy of malignant and benign diseases. As a research tool, siRNA has proven to be highly effective in silencing specific genes and modulating intracellular signaling pathways. However, systemic delivery of siRNA has been more problematic due to degradation and poor cellular uptake. In order to overcome these limitations, a variety of strategies are being developed including new delivery vehicles and chemical modifications. Here, we review potential approaches for the systemic delivery of siRNA for cancer treatment.
Keywords: SiRNA sequences, polyethylene glycol, folate receptor, Antibodies, Positively charged polymers
Mini-Reviews in Medicinal Chemistry
Title: Strategies for In Vivo siRNA Delivery in Cancer
Volume: 8 Issue: 3
Author(s): Anil K. Sood, Angela Sanguino and Gabriel Lopez-Berestein
Affiliation:
Keywords: SiRNA sequences, polyethylene glycol, folate receptor, Antibodies, Positively charged polymers
Abstract: A better understanding of the mechanisms involved in small interference RNA (siRNA) gene silencing opens new horizons for the development of the targeted therapy of malignant and benign diseases. As a research tool, siRNA has proven to be highly effective in silencing specific genes and modulating intracellular signaling pathways. However, systemic delivery of siRNA has been more problematic due to degradation and poor cellular uptake. In order to overcome these limitations, a variety of strategies are being developed including new delivery vehicles and chemical modifications. Here, we review potential approaches for the systemic delivery of siRNA for cancer treatment.
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Cite this article as:
Sood K. Anil, Sanguino Angela and Lopez-Berestein Gabriel, Strategies for In Vivo siRNA Delivery in Cancer, Mini-Reviews in Medicinal Chemistry 2008; 8 (3) . https://dx.doi.org/10.2174/138955708783744074
DOI https://dx.doi.org/10.2174/138955708783744074 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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