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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Novel and Expeditious Approach to Symmetrical and Unsymmetrical 5,5-Spiroimide Building Blocks

Author(s): Aadm Daich, Iyad Allous and Sebastien Comesse

Volume 5, Issue 2, 2008

Page: [73 - 78] Pages: 6

DOI: 10.2174/157017808783743902

Price: $65

Abstract

Symmetrical and unsymmetrical spiro-bis-imides and corresponding 3-methoxycarbonyl succinimides were prepared in very good yields starting from dimethyl malonate and suitable α-bromoacetamides in a one-pot procedure or two-steps sequence, respectively. The mechanistic aspects of these transformations were also discussed.

Keywords: Diazaspiro[4.4]nonane, peptide coupling, spirocyclisation, carbanion, cascade, tandem


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