Abstract
Asymmetric vinylogous aldol reaction is a powerful methodology to introduce a multi functional group in the stereoselective manner. Recently, we have developed highly stereoselective vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals possessing the chiral oxazolidone. Our methodology has been applied to the asymmetric syntheses of natural products to establish the short and efficient routes. This review focuses on the asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products.
Keywords: Vinylogous Mukaiyama aldol reaction, vinylketene N, O-acetal, remote stereoinduction, total synthesis, natural product, polyketide
Mini-Reviews in Organic Chemistry
Title: Asymmetric Vinylogous Mukaiyama Aldol Reactions Using Vinylketene N,O-Acetals in Total Syntheses of Natural Products
Volume: 5 Issue: 1
Author(s): Seijiro Hosokawa and Kuniaki Tatsuta
Affiliation:
Keywords: Vinylogous Mukaiyama aldol reaction, vinylketene N, O-acetal, remote stereoinduction, total synthesis, natural product, polyketide
Abstract: Asymmetric vinylogous aldol reaction is a powerful methodology to introduce a multi functional group in the stereoselective manner. Recently, we have developed highly stereoselective vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals possessing the chiral oxazolidone. Our methodology has been applied to the asymmetric syntheses of natural products to establish the short and efficient routes. This review focuses on the asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products.
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Hosokawa Seijiro and Tatsuta Kuniaki, Asymmetric Vinylogous Mukaiyama Aldol Reactions Using Vinylketene N,O-Acetals in Total Syntheses of Natural Products, Mini-Reviews in Organic Chemistry 2008; 5 (1) . https://dx.doi.org/10.2174/157019308783498197
DOI https://dx.doi.org/10.2174/157019308783498197 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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