Abstract
For examination of glucocorticoid metabolism and identification of hyper and hypocortisolism, various measurements and diagnostic tools are available. After a brief overview of the physiology of glucocorticoid secretion and glucocorticoid actions, the currently used measurements for blood, saliva, and urine samples and the corresponding physiological and metabolic implications are critically reviewed. A special emphasis is placed on the potential of 24-h urine analyses to assess not only glucocorticoid secretion, but also functional glucocorticoid activity.
Keywords: Glucocorticoid measurements, cortisol, cortisone, urinary free steroids, functional glucocorticoid activity, 11betahydroxysteroid dehydrogenase, 5alpha-reductase, 24-h urine collection, children
Mini-Reviews in Medicinal Chemistry
Title: Glucocorticoid Measurements in Health and Disease - Metabolic Implications and the Potential of 24-h Urine Analyses
Volume: 8 Issue: 2
Author(s): Thomas Remer, Christiane Maser-Gluth and Stefan A. Wudy
Affiliation:
Keywords: Glucocorticoid measurements, cortisol, cortisone, urinary free steroids, functional glucocorticoid activity, 11betahydroxysteroid dehydrogenase, 5alpha-reductase, 24-h urine collection, children
Abstract: For examination of glucocorticoid metabolism and identification of hyper and hypocortisolism, various measurements and diagnostic tools are available. After a brief overview of the physiology of glucocorticoid secretion and glucocorticoid actions, the currently used measurements for blood, saliva, and urine samples and the corresponding physiological and metabolic implications are critically reviewed. A special emphasis is placed on the potential of 24-h urine analyses to assess not only glucocorticoid secretion, but also functional glucocorticoid activity.
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Cite this article as:
Remer Thomas, Maser-Gluth Christiane and Wudy A. Stefan, Glucocorticoid Measurements in Health and Disease - Metabolic Implications and the Potential of 24-h Urine Analyses, Mini-Reviews in Medicinal Chemistry 2008; 8 (2) . https://dx.doi.org/10.2174/138955708783498096
DOI https://dx.doi.org/10.2174/138955708783498096 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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