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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Helicobacter pylori Interference with Micronutrients and Orally AdministeredDrugs:ANewMechanism Explaining its Role in Extragastric Disorders

Author(s): A. Pietroiusti, A. Galante, A. Magrini and A. Bergamaschi

Volume 8, Issue 2, 2008

Page: [135 - 141] Pages: 7

DOI: 10.2174/138955708783498177

Price: $65

Abstract

There is an increasing evidence that Helicobacter pylori may interfere with gastrointestinal metabolism of micronutrients and drugs such as iron, cobalamin, thyroxine and levodopa, with relevant clinical effects. In this review we examine the strength of the causal association and the plausible pathophysiologic mechanisms underlying these adverse effects.

Keywords: Helicobacter pylori, iron, cobalamin, thyroxine, levodopa, malabsorption, gastritis, gastric acidity


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