Flavylium Salts as Precursors of Biologically Active Chalcones

Title: Flavylium Salts as Precursors of Biologically Active Chalcones

Volume: 5 Issue: 1

Author(s): Karl A. Werbovetz, Tesmol G. George, Julian Richard, Todd Barszcz and Jeffrey Capers

Affiliation:

Keywords: Leishmania, Trypanosome, Chalcone, Flavylium salt

Abstract: Several flavylium salts showed potent (albeit nonselective) activity against L. donovani axenic amastigotes and T. b. brucei bloodstream forms in vitro (IC50 values ranging from 0.75 to 35 μM). The trans-chalcone, which forms from the corresponding flavylium salt at neutral pH in aqueous solution, is proposed to be the active species.

Cite this article as:

Werbovetz A. Karl, George G. Tesmol, Richard Julian, Barszcz Todd and Capers Jeffrey, Flavylium Salts as Precursors of Biologically Active Chalcones, Letters in Drug Design & Discovery 2008; 5 (1) . https://dx.doi.org/10.2174/157018008783406697