Design and Synthesis of 2-Azetidinone Cholesterol Absorption Inhibitors

Title: Design and Synthesis of 2-Azetidinone Cholesterol Absorption Inhibitors

Volume: 5 Issue: 1

Author(s): Huibin Zhang, Yubin Wang, Rui Zhao, Wenlong Huang, Yunman Li and Jinpei Zhou

Affiliation:

Keywords: 2-Azetidinones, C-3 sidechain, Cholesterol absorption inhibition activity

Abstract: In this paper we reported the design, synthesis of a series 2-azetidinones with ester or amide group in C-3 sidechain. Their cholesterol absorption inhibition activity was assessed in orally dosed, cholesterol-fed hamsters. It was demonstrated that compound 20c∼d with amid group in C-3 sidechain exhibited high cholesterol absorption inhibition activity.

Cite this article as:

Zhang Huibin, Wang Yubin, Zhao Rui, Huang Wenlong, Li Yunman and Zhou Jinpei, Design and Synthesis of 2-Azetidinone Cholesterol Absorption Inhibitors, Letters in Drug Design & Discovery 2008; 5 (1) . https://dx.doi.org/10.2174/157018008783406741