In Silico Modulation of HMGN-1 Binding to Histones and Gene Expression by Interplay of Phosphorylation and O-GlcNAc Modification

Title: In Silico Modulation of HMGN-1 Binding to Histones and Gene Expression by Interplay of Phosphorylation and O-GlcNAc Modification

Volume: 15 Issue: 2

Author(s): Nasir-ud-Din, Ishtiaq Ahmad, Tehmina S. Khan, Daniel C. Hoessli, Evelyne Walker-Nasir, Afshan Kaleem, Abdul R. Shakoori, Tehmina S. Khan, Daniel C. Hoessli and Abdul R. Shakoori

Affiliation:

Keywords: HMGN-1, chromatin, nucleosome, histones, post-translational modifications, Yin Yang sites

Abstract: Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplasm and back to nucleus, consequently modulating gene expression.

Cite this article as:

Nasir-ud-Din , Ahmad Ishtiaq, Khan S. Tehmina, Hoessli C. Daniel, Walker-Nasir Evelyne, Kaleem Afshan, Shakoori R. Abdul, S. Khan Tehmina, C. Hoessli Daniel and R. Shakoori Abdul, In Silico Modulation of HMGN-1 Binding to Histones and Gene Expression by Interplay of Phosphorylation and O-GlcNAc Modification, Protein & Peptide Letters 2008; 15 (2) . https://dx.doi.org/10.2174/092986608783489607