Abstract
Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Inhibitors of PTP1B showed increased insulin sensitivity and normalize plasma glucose level and thus are useful therapeutic agents for the treatment of diabetes. A series of functionalized 4,5-dihydronaphthofurans and dibenzofurans were synthesized, studied through molecular docking and evaluated for their PTP1B inhibitory activity.
Keywords: Diabetes, PTP1B inhibitor, 4,5-dihydronaphthofuran, dibenzofuran, molecular docking
Medicinal Chemistry
Title: Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans
Volume: 4 Issue: 1
Author(s): Atul Goel, Manish Dixit, Uzma Saeed, Amit Kumar, Mohammad Imran Siddiqi, Akhilesh K. Tamrakar and Arvind K. Srivastava
Affiliation:
Keywords: Diabetes, PTP1B inhibitor, 4,5-dihydronaphthofuran, dibenzofuran, molecular docking
Abstract: Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Inhibitors of PTP1B showed increased insulin sensitivity and normalize plasma glucose level and thus are useful therapeutic agents for the treatment of diabetes. A series of functionalized 4,5-dihydronaphthofurans and dibenzofurans were synthesized, studied through molecular docking and evaluated for their PTP1B inhibitory activity.
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Goel Atul, Dixit Manish, Saeed Uzma, Kumar Amit, Siddiqi Imran Mohammad, Tamrakar K. Akhilesh and Srivastava K. Arvind, Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans, Medicinal Chemistry 2008; 4 (1) . https://dx.doi.org/10.2174/157340608783331515
DOI https://dx.doi.org/10.2174/157340608783331515 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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