Mechanisms of Intimal Hyperplasia Learned from a Murine Carotid Artery Ligation Model

Title: Mechanisms of Intimal Hyperplasia Learned from a Murine Carotid Artery Ligation Model

Volume: 6 Issue: 1

Author(s): Le-Ning Zhang, John F. Parkinson, Christopher Haskell and Yi-Xin Wang

Affiliation:

Keywords: Intimal hyperplasia, carotid artery ligation, hyperlipidemia, endothelial dysfunction, protease, angiotensin II

Abstract: The murine carotid artery ligation (CAL) model has been widely used in the research of intimal hyperplasia, a major pathological process in vascular diseases, such as atherosclerosis and restenosis after angioplasty. Using a variety of gene knockout or transgenic mice and different pharmacological interventions, these studies have yielded significant new findings that contribute not only to unraveling the basic molecular mechanisms involved in the pathogenesis of intimal hyperplasia, but also to the identification of novel targets for intervention of these diseases. The current review outlines the findings derived from the murine CAL model, including studies run by the authors, covering the impacts of hyperlipidemia, pro-inflammatory factors, endothelial dysfunction, protease activity and growth mediators on neointimal hyperplasia.

Cite this article as:

Zhang Le-Ning, Parkinson F. John, Haskell Christopher and Wang Yi-Xin, Mechanisms of Intimal Hyperplasia Learned from a Murine Carotid Artery Ligation Model, Current Vascular Pharmacology 2008; 6 (1) . https://dx.doi.org/10.2174/157016108783331321