Design, Synthesis and Biological Activity of A-C8/C-C2-Linked 6-Chloropurine-Pyrrolobenzodiazepine Hybrids as Anticancer Agents

Title: Design, Synthesis and Biological Activity of A-C8/C-C2-Linked 6-Chloropurine-Pyrrolobenzodiazepine Hybrids as Anticancer Agents

Volume: 4 Issue: 8

Author(s): Ahmed Kamal, N. Shankaraiah, K. Laxma Reddy, V. Devaiah, Aarti Juvekar and Subrata Sen

Affiliation:

Keywords: Pyrrolo[2,1-c][1,4]benzodiazepines, 6-chloropurine nucleosides, DNA-binding affinity, Anticancer activity

Abstract: New A-C8 and C-C2-linked 6-chloropurine-pyrrolo[2,1-c][1,4]benzodiazepine hybrids have been prepared and evaluated for their anticancer potential. The molecular modeling studies might be explained in terms of effect of the molecule on binding in the minor groove of DNA and also comparison to both A-C8/C-C2-position of the PBD. These PBD conjugates have shown DNA-binding ability and promising anticancer activity.

Cite this article as:

Kamal Ahmed, Shankaraiah N., Reddy Laxma K., Devaiah V., Juvekar Aarti and Sen Subrata, Design, Synthesis and Biological Activity of A-C8/C-C2-Linked 6-Chloropurine-Pyrrolobenzodiazepine Hybrids as Anticancer Agents, Letters in Drug Design & Discovery 2007; 4 (8) . https://dx.doi.org/10.2174/157018007782794482