Abstract
The structure of Escherichia coli chaperonin GroEL was studied using various experimental tools. Such studies produced information about its structure with increasing details. Moreover, remarkable advances in experimental methods provided a step forward in understanding the reaction cycle involved in GroEL-mediated protein folding. In the current review we summarize recent progress, focus on the structure of GroEL and understand the mechanism involved in GroEL-mediated protein folding. This review is divided into the following sections: (i) Section 1 provides basic understanding on protein folding, (ii) Section 2 not only describes various tools used to elucidate the structural aspects of GroEL but also provides details about its structure with particular emphasis, (iii) Section 3 describes allosteric transitions and the reaction cycle involved in GroEL-mediated protein folding, (iv) Section 4 explains iterative annealing and smoothing of the energy landscape model and finally (v) Section 5 discusses applications and recent progress.
Keywords: Chaperonin, Escherichia coli, iterative annealing, molecular chaperonins, GroEL, GroES, protein folding
Current Protein & Peptide Science
Title: Chaperonin GroEL: Structure and Reaction Cycle
Volume: 8 Issue: 5
Author(s): K. Ananda Krishna, G. Venkateswara Rao and K. R.S. Sambasiva Rao
Affiliation:
Keywords: Chaperonin, Escherichia coli, iterative annealing, molecular chaperonins, GroEL, GroES, protein folding
Abstract: The structure of Escherichia coli chaperonin GroEL was studied using various experimental tools. Such studies produced information about its structure with increasing details. Moreover, remarkable advances in experimental methods provided a step forward in understanding the reaction cycle involved in GroEL-mediated protein folding. In the current review we summarize recent progress, focus on the structure of GroEL and understand the mechanism involved in GroEL-mediated protein folding. This review is divided into the following sections: (i) Section 1 provides basic understanding on protein folding, (ii) Section 2 not only describes various tools used to elucidate the structural aspects of GroEL but also provides details about its structure with particular emphasis, (iii) Section 3 describes allosteric transitions and the reaction cycle involved in GroEL-mediated protein folding, (iv) Section 4 explains iterative annealing and smoothing of the energy landscape model and finally (v) Section 5 discusses applications and recent progress.
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Cite this article as:
Krishna Ananda K., Rao Venkateswara G. and Rao R.S. Sambasiva K., Chaperonin GroEL: Structure and Reaction Cycle, Current Protein & Peptide Science 2007; 8 (5) . https://dx.doi.org/10.2174/138920307782411455
DOI https://dx.doi.org/10.2174/138920307782411455 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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