Abstract
The lectin from the seeds of Canavalia brasiliensis (Con Br) was tested for its renal effects using the isolated perfusion rat kidney method. Three different doses were examined (3,10 and 30 microgram / ml), which were compared with a control group. The control group was perfused with only Krebs-Henseleit solution containing 6 percent BSA. Con Br caused diuresis and natriuresis, with a mild alteration on the perfusion pressure. Probably the lectin is inhibiting the Na+ / K+ / 2Cl- transporter present in the thick ascending limb of the Henle´s loop.
Keywords: LECTIN, CANAVALIA, BRASILIENSIS, Diocleinae, Phaseolae, Con Br, Eicosanoids, Phaseolus vulgaris, Canavalia ensiformis
Protein & Peptide Letters
Title: Renal Effects Of The Lectin From Canavalia Brasiliensis Seeds
Volume: 8 Issue: 6
Author(s): Edson H. Teixeira, Alexandre Havt, Paulo S.F. Barbosa, Dalgimar B. Meneses, Manasses C. Fonteles, Helena S.A. Monteiro, Alexander H. Sampaio and Benildo S. Cavada
Affiliation:
Keywords: LECTIN, CANAVALIA, BRASILIENSIS, Diocleinae, Phaseolae, Con Br, Eicosanoids, Phaseolus vulgaris, Canavalia ensiformis
Abstract: The lectin from the seeds of Canavalia brasiliensis (Con Br) was tested for its renal effects using the isolated perfusion rat kidney method. Three different doses were examined (3,10 and 30 microgram / ml), which were compared with a control group. The control group was perfused with only Krebs-Henseleit solution containing 6 percent BSA. Con Br caused diuresis and natriuresis, with a mild alteration on the perfusion pressure. Probably the lectin is inhibiting the Na+ / K+ / 2Cl- transporter present in the thick ascending limb of the Henle´s loop.
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Cite this article as:
Teixeira H. Edson, Havt Alexandre, Barbosa S.F. Paulo, Meneses B. Dalgimar, Fonteles C. Manasses, Monteiro S.A. Helena, Sampaio H. Alexander and Cavada S. Benildo, Renal Effects Of The Lectin From Canavalia Brasiliensis Seeds, Protein & Peptide Letters 2001; 8 (6) . https://dx.doi.org/10.2174/0929866013409094
DOI https://dx.doi.org/10.2174/0929866013409094 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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