Abstract
Significant advances have been made in the field of peptide chemistry, especially in the design of synthetic peptide immunogens which has led to new concepts and strategies for human vaccine development. This article reviews some of these technological advances and approaches to vaccine design including the multiple antigenic peptide system, the lipid polylysine core peptide system, the polymerization of peptides into multivalent immunogens and self adjuvanting synthetic peptide-based immunogens.
Keywords: receptor (TCR), antigen presenting cells (APC), immunogens, B-cell epitopes
Mini-Reviews in Medicinal Chemistry
Title: Technological Advances in Antigen Delivery and Synthetic Peptide Vaccine Developmental Strategies
Volume: 1 Issue: 4
Author(s): C. Olive, I. Toth and D. Jackson
Affiliation:
Keywords: receptor (TCR), antigen presenting cells (APC), immunogens, B-cell epitopes
Abstract: Significant advances have been made in the field of peptide chemistry, especially in the design of synthetic peptide immunogens which has led to new concepts and strategies for human vaccine development. This article reviews some of these technological advances and approaches to vaccine design including the multiple antigenic peptide system, the lipid polylysine core peptide system, the polymerization of peptides into multivalent immunogens and self adjuvanting synthetic peptide-based immunogens.
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Cite this article as:
Olive C., Toth I. and Jackson D., Technological Advances in Antigen Delivery and Synthetic Peptide Vaccine Developmental Strategies, Mini-Reviews in Medicinal Chemistry 2001; 1 (4) . https://dx.doi.org/10.2174/1389557013406666
DOI https://dx.doi.org/10.2174/1389557013406666 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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