Abstract
Over the past several years, neurotrophic factors have made considerable progress from the laboratory into the clinic. Evidence from preclinical and clinical studies indicates that it may be possible to use neurotrophic factors to prevent, slow the progression of, or even reverse the effects of a number of neurodegenerative diseases and other types of insults in both the central and peripheral nervous system. Their potential importance in the development of therapeutic agents against neurodegenerative disorders and nerve injury has led to a flurry of activity towards understanding their structure, function and signalling mechanisms. Approaches to develop pharmacological agents that target neurotrophic factors, their receptors or neurotrophic factors signalling pathways have been attempted. This review focuses on some of the major themes and lines of mechanistic and therapeutic advances in this fast-moving field of neuroscience.
Keywords: Neurotrophic Molecules, Neurode-generation, neurodegenerative diseases, neurotrophic factors, factor (NGF), brain-derived, neurotrophic factor, neurotrophin-3 (NT-3), neurotrophin, neurotrophin-6 (NT-6)
Current Protein & Peptide Science
Title: Development of Neurotrophic Molecules for Treatment of Neurode-generation
Volume: 2 Issue: 3
Author(s): Zhe-yu Chen, Li Cao, Li-mei Wang, Chao Guo, Jun-Li Ye, Yan-Feng Chai and Zhi-Yong Yan
Affiliation:
Keywords: Neurotrophic Molecules, Neurode-generation, neurodegenerative diseases, neurotrophic factors, factor (NGF), brain-derived, neurotrophic factor, neurotrophin-3 (NT-3), neurotrophin, neurotrophin-6 (NT-6)
Abstract: Over the past several years, neurotrophic factors have made considerable progress from the laboratory into the clinic. Evidence from preclinical and clinical studies indicates that it may be possible to use neurotrophic factors to prevent, slow the progression of, or even reverse the effects of a number of neurodegenerative diseases and other types of insults in both the central and peripheral nervous system. Their potential importance in the development of therapeutic agents against neurodegenerative disorders and nerve injury has led to a flurry of activity towards understanding their structure, function and signalling mechanisms. Approaches to develop pharmacological agents that target neurotrophic factors, their receptors or neurotrophic factors signalling pathways have been attempted. This review focuses on some of the major themes and lines of mechanistic and therapeutic advances in this fast-moving field of neuroscience.
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Cite this article as:
Chen Zhe-yu, Cao Li, Wang Li-mei, Guo Chao, Ye Jun-Li, Chai Yan-Feng and Yan Zhi-Yong, Development of Neurotrophic Molecules for Treatment of Neurode-generation, Current Protein & Peptide Science 2001; 2 (3) . https://dx.doi.org/10.2174/1389203013381125
DOI https://dx.doi.org/10.2174/1389203013381125 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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