Inhibition of Fungal Aldose Reductase

Title: Inhibition of Fungal Aldose Reductase

Volume: 8 Issue: 5

Author(s): Ya-Jun Zheng, Yong Tao, Wei Zhang and Douglas B. Jordan

Affiliation:

Keywords: fungal ALDOSE REDUCTASE, Magnaporthe grisea

Abstract: Aldose reductase (AR) was cloned from the fungal pathogen, Magnaporthe grisea, expressed in Escherichia coli and purified to homogeneity. An experimental fungicide inhibits the M. grisea AR uncompetitively with respect to its aldehyde substrate with a Ki of 130 nM, the potency suggesting that AR is a biochemical target of the fungicide. The M. grisea AR has a high kcat and large differences in substrate specificities.

Cite this article as:

Zheng Ya-Jun, Tao Yong, Zhang Wei and Jordan B. Douglas, Inhibition of Fungal Aldose Reductase, Protein & Peptide Letters 2001; 8 (5) . https://dx.doi.org/10.2174/0929866013409210