Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) have unacceptable morbidity and mortality due to their gastrointestinal toxicity. Attempts so far to improve the safety profile of NSAIDs have met with limited clinical acceptance. Nitric oxide (NO) functions as an endogenous mediator of gastric mucosal health and defense. Recent medicinal chemistry approaches attempt to exploit the tissue-protective function of NO against NSAID-induced gastric injury. Both nitroxybutyl-ester and nitrosothiol NSAID derivatives have been synthesized. Profiling of these NO-donating NSAIDs in both the laboratory and the clinic suggests that they might offer a unique solution to the problem of NSAID-induced gastropathy without sacrificing the well-accepted pharmacological activity of these agents in the management of pain and inflammation.
Keywords: Nonsteroidal Anti inflammatory Drugs, Chronic NSAID therapy, nitroxybutyl ester, Topical irritation, vascular relaxing factor, hydrated ferrous ion, anti inflammatory activities, chlorobutyl bromide, plasma naproxen level, cultured murine, Intraperitoneal diclofenac
Mini-Reviews in Medicinal Chemistry
Title: Nitric Oxide-Releasing Nonsteroidal Anti-inflammatory Drugs Novel Gastrointestinal-Sparing Drugs
Volume: 1 Issue: 1
Author(s): Upul Bandarage and David R. Janero
Affiliation:
Keywords: Nonsteroidal Anti inflammatory Drugs, Chronic NSAID therapy, nitroxybutyl ester, Topical irritation, vascular relaxing factor, hydrated ferrous ion, anti inflammatory activities, chlorobutyl bromide, plasma naproxen level, cultured murine, Intraperitoneal diclofenac
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) have unacceptable morbidity and mortality due to their gastrointestinal toxicity. Attempts so far to improve the safety profile of NSAIDs have met with limited clinical acceptance. Nitric oxide (NO) functions as an endogenous mediator of gastric mucosal health and defense. Recent medicinal chemistry approaches attempt to exploit the tissue-protective function of NO against NSAID-induced gastric injury. Both nitroxybutyl-ester and nitrosothiol NSAID derivatives have been synthesized. Profiling of these NO-donating NSAIDs in both the laboratory and the clinic suggests that they might offer a unique solution to the problem of NSAID-induced gastropathy without sacrificing the well-accepted pharmacological activity of these agents in the management of pain and inflammation.
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Cite this article as:
Bandarage Upul and Janero R. David, Nitric Oxide-Releasing Nonsteroidal Anti-inflammatory Drugs Novel Gastrointestinal-Sparing Drugs, Mini-Reviews in Medicinal Chemistry 2001; 1 (1) . https://dx.doi.org/10.2174/1389557013407160
DOI https://dx.doi.org/10.2174/1389557013407160 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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