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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Polyamine Metabolism as Chemotherapeutic Target in Protozoan Parasites

Author(s): C. J. Bacchi and N. Yarlett

Volume 2, Issue 6, 2002

Page: [553 - 563] Pages: 11

DOI: 10.2174/1389557023405549

Price: $65

Abstract

Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes and related pathways.

Keywords: chemotherapeutic target, protozoan parasites, polyamine analogs, ornithine decarboxylase, backconversion pathway, african trypanosomes, nucleoside transporters, dfmo


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