Abstract
αVβ3 integrin, a cell surface protein, has been targeted by a variety of natural and synthetic antagonists in the search for potential cancer and osteoporosis drug candidates. This review discusses chemical and structural requirements for activity and selectivity deduced from SAR studies and draws a tentative picture of the pharmacophore.
Keywords: vitronectin receptor, activity and selectivity, cell surface protein, antagonists, heterodimeric non-covalent proteins, tumour metastasis, thrombotic disorder treatment, snake venom proteins, pseudo-peptides, pseudo-peptidic antagonists
Mini-Reviews in Medicinal Chemistry
Title: Vitronectin Receptor -αVβ3 Integrin- Antagonists: Chemical and Structural Requirements for Activity and Selectivity
Volume: 2 Issue: 6
Author(s): Christophe Henry, Nicolas Moitessier and Yves Chapleur
Affiliation:
Keywords: vitronectin receptor, activity and selectivity, cell surface protein, antagonists, heterodimeric non-covalent proteins, tumour metastasis, thrombotic disorder treatment, snake venom proteins, pseudo-peptides, pseudo-peptidic antagonists
Abstract: αVβ3 integrin, a cell surface protein, has been targeted by a variety of natural and synthetic antagonists in the search for potential cancer and osteoporosis drug candidates. This review discusses chemical and structural requirements for activity and selectivity deduced from SAR studies and draws a tentative picture of the pharmacophore.
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Cite this article as:
Henry Christophe, Moitessier Nicolas and Chapleur Yves, Vitronectin Receptor -αVβ3 Integrin- Antagonists: Chemical and Structural Requirements for Activity and Selectivity, Mini-Reviews in Medicinal Chemistry 2002; 2 (6) . https://dx.doi.org/10.2174/1389557023405602
DOI https://dx.doi.org/10.2174/1389557023405602 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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