Abstract
Most insecticides are potent neurotoxicants that act on various neuroreceptors and ion channels. However, the major target receptors are limited to sodium channels, GABA receptors, and nicotinic acetylcholine receptors. DDT and pyrethroids act similarly on sodium channels to keep them open leading to hyperexcitation. Indoxacarb inhibits sodium channels and certain subtypes of nicotinic receptors. Dieldrin, lindane and fipronil block GABA receptors. Imidacloprid modulates nicotinic receptors in a complex manner. Spinosads major target site appears to be nicotinic receptors.
Keywords: imidacloprid, insecticide, Ion channel, neurotoxicant, indoxacarb
Mini-Reviews in Medicinal Chemistry
Title: Nerve Membrane Ion Channels as the Target Site of Insecticides
Volume: 2 Issue: 4
Author(s): Toshio Narahashi
Affiliation:
Keywords: imidacloprid, insecticide, Ion channel, neurotoxicant, indoxacarb
Abstract: Most insecticides are potent neurotoxicants that act on various neuroreceptors and ion channels. However, the major target receptors are limited to sodium channels, GABA receptors, and nicotinic acetylcholine receptors. DDT and pyrethroids act similarly on sodium channels to keep them open leading to hyperexcitation. Indoxacarb inhibits sodium channels and certain subtypes of nicotinic receptors. Dieldrin, lindane and fipronil block GABA receptors. Imidacloprid modulates nicotinic receptors in a complex manner. Spinosads major target site appears to be nicotinic receptors.
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Cite this article as:
Narahashi Toshio, Nerve Membrane Ion Channels as the Target Site of Insecticides, Mini-Reviews in Medicinal Chemistry 2002; 2 (4) . https://dx.doi.org/10.2174/1389557023405927
DOI https://dx.doi.org/10.2174/1389557023405927 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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