Abstract
Certain glycosidase inhibitors possess potent antiviral, antitumour and antidiabetic properties. Glyconic acid lactones, the earliest glycosidase inhibitors identified, have planar anomeric carbons that mimic the transition state of glycoside hydrolysis. Other classes include lactams, glycals, epoxides, halides and sulfonium ions, the latter based on the natural product salacinol from an antidiabetic herb.
Keywords: glycosidase inhibitors, glucosidase, mannosidase, galactosidase, sialidase, salacinol, cyclophellitol
Mini-Reviews in Medicinal Chemistry
Title: Back to (non)-Basics: Recent Developments in Neutral and Charge- Balanced Glycosidase Inhibitors
Volume: 3 Issue: 7
Author(s): Todd A. Houston and Joanne T. Blanchfield
Affiliation:
Keywords: glycosidase inhibitors, glucosidase, mannosidase, galactosidase, sialidase, salacinol, cyclophellitol
Abstract: Certain glycosidase inhibitors possess potent antiviral, antitumour and antidiabetic properties. Glyconic acid lactones, the earliest glycosidase inhibitors identified, have planar anomeric carbons that mimic the transition state of glycoside hydrolysis. Other classes include lactams, glycals, epoxides, halides and sulfonium ions, the latter based on the natural product salacinol from an antidiabetic herb.
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Cite this article as:
Houston A. Todd and Blanchfield T. Joanne, Back to (non)-Basics: Recent Developments in Neutral and Charge- Balanced Glycosidase Inhibitors, Mini-Reviews in Medicinal Chemistry 2003; 3 (7) . https://dx.doi.org/10.2174/1389557033487827
DOI https://dx.doi.org/10.2174/1389557033487827 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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