Abstract
Histamine is a biogenic amine that plays a host of physiological roles and the three major functions for histamine have been largely defined by the activity of three receptors. The inflammatory wheal and flare response is driven by the H1 receptor [1]. The H2 receptor controls gastric acid secretion in the gut [2]. The H3 receptor is involved in neurotransmitter release in the central nervous system [3]. The recent discovery of the histamine H4 receptor by several groups has lead to the re-evaluation of the physiological role for histamine.
Keywords: g-protein coupled receptors, amino acid, histamine receptors, porcine receptor, antagonist, agonists, ligands, thioperamide
Mini-Reviews in Medicinal Chemistry
Title: The Histamine H4 Receptor and Potential Therapeutic Uses for H4 Ligands
Volume: 4 Issue: 9
Author(s): Jill A. Jablonowski, Nicholas I. Carruthers and Robin L. Thurmond
Affiliation:
Keywords: g-protein coupled receptors, amino acid, histamine receptors, porcine receptor, antagonist, agonists, ligands, thioperamide
Abstract: Histamine is a biogenic amine that plays a host of physiological roles and the three major functions for histamine have been largely defined by the activity of three receptors. The inflammatory wheal and flare response is driven by the H1 receptor [1]. The H2 receptor controls gastric acid secretion in the gut [2]. The H3 receptor is involved in neurotransmitter release in the central nervous system [3]. The recent discovery of the histamine H4 receptor by several groups has lead to the re-evaluation of the physiological role for histamine.
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Cite this article as:
Jablonowski A. Jill, Carruthers I. Nicholas and Thurmond L. Robin, The Histamine H4 Receptor and Potential Therapeutic Uses for H4 Ligands, Mini-Reviews in Medicinal Chemistry 2004; 4 (9) . https://dx.doi.org/10.2174/1389557043403152
DOI https://dx.doi.org/10.2174/1389557043403152 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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