Abstract
The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimesconflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.
Keywords: histamine, h3, gpcr, agonist, isoform, activity, efficacy, affinity
Mini-Reviews in Medicinal Chemistry
Title: Histamine H3 Receptor Agonists
Volume: 4 Issue: 9
Author(s): I. J.P. De Esch and K. J. Belzar
Affiliation:
Keywords: histamine, h3, gpcr, agonist, isoform, activity, efficacy, affinity
Abstract: The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimesconflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.
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Cite this article as:
De Esch J.P. I. and Belzar J. K., Histamine H3 Receptor Agonists, Mini-Reviews in Medicinal Chemistry 2004; 4 (9) . https://dx.doi.org/10.2174/1389557043403134
DOI https://dx.doi.org/10.2174/1389557043403134 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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