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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Histamine H3 Receptor Agonists

Author(s): I. J.P. De Esch and K. J. Belzar

Volume 4, Issue 9, 2004

Page: [955 - 963] Pages: 9

DOI: 10.2174/1389557043403134

Price: $65

Abstract

The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimesconflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.

Keywords: histamine, h3, gpcr, agonist, isoform, activity, efficacy, affinity


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