Abstract
β-lactam ring-containing compounds such as penicillins, ampicillin, amoxicillin, cephalosporins and carbapenem are among the most famous antibiotics. This article reviews the recent developments in the study of such compounds. The introductory paragraph, which highlights the significance of the subject and cites most of the leading references of the previous century, is followed by an overview of β-lactams and some novel methodologies for the synthesis of bi-, tri- and polycyclic derivatives. The rest of the sections deal with design, synthesis and biological activity of monobactams and carbapenems. Many of them have potential antibacterial activity, even against some resistant strains, and enzyme inhibitory activity.
Keywords: Lactam, carbapenem, Staudinger reaction, amino acid cyclization, antimicrobials, cholesterol absorption, inhibitors, enzyme inhibitors, anticancer
Mini-Reviews in Medicinal Chemistry
Title: β-Lactams in the New Millennium. Part-I: Monobactams and Carbapenems
Volume: 4 Issue: 1
Author(s): G.S. Singh
Affiliation:
Keywords: Lactam, carbapenem, Staudinger reaction, amino acid cyclization, antimicrobials, cholesterol absorption, inhibitors, enzyme inhibitors, anticancer
Abstract: β-lactam ring-containing compounds such as penicillins, ampicillin, amoxicillin, cephalosporins and carbapenem are among the most famous antibiotics. This article reviews the recent developments in the study of such compounds. The introductory paragraph, which highlights the significance of the subject and cites most of the leading references of the previous century, is followed by an overview of β-lactams and some novel methodologies for the synthesis of bi-, tri- and polycyclic derivatives. The rest of the sections deal with design, synthesis and biological activity of monobactams and carbapenems. Many of them have potential antibacterial activity, even against some resistant strains, and enzyme inhibitory activity.
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Cite this article as:
G.S. Singh , β-Lactams in the New Millennium. Part-I: Monobactams and Carbapenems, Mini-Reviews in Medicinal Chemistry 2004; 4 (1) . https://dx.doi.org/10.2174/1389557043487501
DOI https://dx.doi.org/10.2174/1389557043487501 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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