Abstract
The current status in rational drug design using homology-based models is discussed, with focus on template selection, model building, model verification and strategies for drug design based on model structures. A novel approach for identification of unique binding site features from homology-based models, Protein Alpha Shape Similarity Analysis (PASSA) is described.
Keywords: homology model, drug design, template selection, model verification, protein alpha shape similarity analysis
Mini-Reviews in Medicinal Chemistry
Title: Homology-Based Modelling of Targets for Rational Drug Design
Volume: 4 Issue: 7
Author(s): Heather Wieman, Kristin Tøndel, Endre Anderssen and Finn Drablos
Affiliation:
Keywords: homology model, drug design, template selection, model verification, protein alpha shape similarity analysis
Abstract: The current status in rational drug design using homology-based models is discussed, with focus on template selection, model building, model verification and strategies for drug design based on model structures. A novel approach for identification of unique binding site features from homology-based models, Protein Alpha Shape Similarity Analysis (PASSA) is described.
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Cite this article as:
Wieman Heather, Tøndel Kristin, Anderssen Endre and Drablos Finn, Homology-Based Modelling of Targets for Rational Drug Design, Mini-Reviews in Medicinal Chemistry 2004; 4 (7) . https://dx.doi.org/10.2174/1389557043403639
DOI https://dx.doi.org/10.2174/1389557043403639 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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