Abstract
Frontotemporal Lobar degeneration (FTLD) is one of the most important neurodegenerative conditions, affecting in the presenium, but more recently recognized also in aged population. The strong genetic background, along with autopsy determinations prompted the identification of the two major genes associated to the disease: MAPT gene, and Progranulin (PGRN) gene. In this review, we highlighted the milestones of these discoveries, and their implication for the development of future therapeuthical approaches.
Keywords: Fronto temporal lobak degeneration, MAPT, progranulin, DLDH, PNFA, CBS, PSP, frontal atrophy, FTLD-MND, CHMP2B, language dysfunction, (TAR)-DNA-binding, NCI, ALS
Current Alzheimer Research
Title: Chromosome 17 in Fronto Temporal Lobak Degeneration (FTLD): From MAPT to Progranulin and Back
Volume: 8 Issue: 3
Author(s): A. Alberici, M. Cosseddu, A. Padovani and B. Borroni
Affiliation:
Keywords: Fronto temporal lobak degeneration, MAPT, progranulin, DLDH, PNFA, CBS, PSP, frontal atrophy, FTLD-MND, CHMP2B, language dysfunction, (TAR)-DNA-binding, NCI, ALS
Abstract: Frontotemporal Lobar degeneration (FTLD) is one of the most important neurodegenerative conditions, affecting in the presenium, but more recently recognized also in aged population. The strong genetic background, along with autopsy determinations prompted the identification of the two major genes associated to the disease: MAPT gene, and Progranulin (PGRN) gene. In this review, we highlighted the milestones of these discoveries, and their implication for the development of future therapeuthical approaches.
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Alberici A., Cosseddu M., Padovani A. and Borroni B., Chromosome 17 in Fronto Temporal Lobak Degeneration (FTLD): From MAPT to Progranulin and Back, Current Alzheimer Research 2011; 8 (3) . https://dx.doi.org/10.2174/156720511795563737
DOI https://dx.doi.org/10.2174/156720511795563737 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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